Pazopanib

Pazopanib
Clinical data
Pronunciation/pæˈzoʊpənɪb/ paz-OH-pə-nib
Trade namesVotrient
AHFS/Drugs.comMonograph
MedlinePlusa610013
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth (tablets)
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability21% (14–39%)[1]
Protein binding>99.5%[1][2]
MetabolismLiver: CYP3A4 (major), 1A2 and 2C8 (minor)[2]
Elimination half-life30.9±4 hours[1]
ExcretionFaeces (primary), urine (<4%)[2]
Identifiers
  • 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H23N7O2S
Molar mass437.52 g·mol−1
3D model (JSmol)
  • O=S(=O)(N)c1c(ccc(c1)Nc2nccc(n2)N(c4ccc3c(nn(c3C)C)c4)C)C
  • InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H checkY
  • Key:MQHIQUBXFFAOMK-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pazopanib, sold under the brand name Votrient, is an anti-cancer medication marketed worldwide by Novartis. It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. It has been approved for renal cell carcinoma and soft tissue sarcoma by numerous regulatory administrations worldwide.[3][4][5][6]

  1. ^ a b c "CHMP Assessment Report: Votrient (pazopanib)" (PDF). European Medicines Agency. Retrieved 8 October 2016.
  2. ^ a b c Cite error: The named reference MSR was invoked but never defined (see the help page).
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