Penbutolol

Penbutolol
Clinical data
Trade namesLevatol
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa601091
ATC code
Identifiers
  • (S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H29NO2
Molar mass291.435 g·mol−1
3D model (JSmol)
  • O[C@@H](CNC(C)(C)C)COc1ccccc1C2CCCC2
  • InChI=1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m0/s1 checkY
  • Key:KQXKVJAGOJTNJS-HNNXBMFYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Penbutolol (brand names Levatol, Levatolol, Lobeta, Paginol, Hostabloc, Betapressin) is a medication in the class of beta blockers, used in the treatment of high blood pressure.[1] Penbutolol is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker.[2]: Table 10–2, p 252  Penbutolol is a sympathomimetic drug with properties allowing it to act as a partial agonist at β adrenergic receptors.[3]

It was approved by the FDA in 1987[4] and was withdrawn from the US market by January 2015.[5]

  1. ^ FDA Penbutolol label Last updated Dec 2010
  2. ^ Katzung, Bertram G. Basic and Clinical Pharmacology (13th ed.) McGraw-Hill Education, 2015. ISBN 9780071826419
  3. ^ Frishman WH, Covey S (1990). "Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism". Journal of Clinical Pharmacology. 30 (5): 412–21. doi:10.1002/j.1552-4604.1990.tb03479.x. PMID 2189902. S2CID 12950442.
  4. ^ FDA History NDA 018976
  5. ^ FDA notice in the Federal Register. Jan 9, 2015 Determination That TAGAMET (Cimetidine) Tablets and Other Drug Products Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness