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Philadelphia, the largest city in Pennsylvania and sixth-largest city in the nation, with a population of 1,603,797, and the center of the Philadelphia-Camden-Wilmington, PA-NJ-DE-MD metropolitan area, the state's largest metropolitan statistical area and nation's seventh-largest with a population of 6,245,051

Pittsburgh, the second-largest city in Pennsylvania, and the center of Greater Pittsburgh, the state's second-largest metropolitan area

Pennsylvania has 14 U.S. Census Bureau-designated metropolitan statistical areas (MSAs) and four combined statistical areas (CSAs). As of 2020, Philadelphia, the seventh-largest United States metropolitan area, is the state's largest metropolitan area followed by Pittsburgh and Allentown.^[1]

^ "Metropolitan and Micropolitan Statistical Areas Population Totals and Components of Change: 2010-2020". United States Census Bureau, Population Division. April 2020. Retrieved May 20, 2021.