Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a protein that in humans is encoded by the POSTN gene.[5][6] Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells.[7]
Periostin is a gla domain vitamin K dependent factor.[8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000133110 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027750 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Takeshita S, Kikuno R, Tezuka K, Amann E (Aug 1993). "Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I". The Biochemical Journal. 294. 294 (1): 271–8. doi:10.1042/bj2940271. PMC 1134594. PMID 8363580.
- ^ "Entrez Gene: POSTN periostin, osteoblast specific factor".
- ^ Cite error: The named reference
pmid12235007was invoked but never defined (see the help page). - ^ Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD, Galipeau J (Jun 2008). "Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells". The Journal of Biological Chemistry. 283 (26): 17991–8001. doi:10.1074/jbc.M708029200. PMID 18450759.