Peroxiredoxin 1

PRDX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RII, 3HY2, 4XCS
Identifiers
Aliases	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2, Peroxiredoxin 1
External IDs	OMIM: 176763; MGI: 99523; HomoloGene: 99789; GeneCards: PRDX1; OMA:PRDX1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	45,542,732 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,558,019 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; palpebral conjunctiva; ; C1 segment; ; mucosa of esophagus; ; ganglionic eminence; ; gums; ; gingival epithelium;
	Top expressed in
	vas deferens; ; primitive streak; ; endothelial cell of lymphatic vessel; ; right kidney; ; Gonadal ridge; ; efferent ductule; ; lobe of prostate; ; stroma of bone marrow; ; iris; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antioxidant activity; protein binding; peroxiredoxin activity; identical protein binding; oxidoreductase activity; thioredoxin peroxidase activity; peroxidase activity; RNA binding; cadherin binding;
Cellular component	cytoplasm; cytosol; melanosome; myelin sheath; mitochondrion; extracellular exosome; nucleus; extracellular matrix; extracellular space;
Biological process	skeletal system development; removal of superoxide radicals; response to oxidative stress; retina homeostasis; erythrocyte homeostasis; hydrogen peroxide catabolic process; cell population proliferation; regulation of stress-activated MAPK cascade; natural killer cell mediated cytotoxicity; cell redox homeostasis; natural killer cell activation; response to reactive oxygen species; cellular response to oxidative stress; regulation of NIK/NF-kappaB signaling; leukocyte activation;
	Sources:Amigo / QuickGO
Orthologs
	5052
	18477
	ENSG00000117450
	ENSMUSG00000028691
	Q06830
	P35700
	NM_181697; NM_001202431; NM_002574; NM_181696
	NM_011034
	NP_001189360; NP_002565; NP_859047; NP_859048
	NP_035164
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028691 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Prospéri MT, Ferbus D, Karczinski I, Goubin G (May 1993). "A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins". The Journal of Biological Chemistry. 268 (15): 11050–6. doi:10.1016/S0021-9258(18)82090-7. PMID 8496166.
^ "Entrez Gene: PRDX1 peroxiredoxin 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117450 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028691 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8496166-5] Prospéri MT, Ferbus D, Karczinski I, Goubin G (May 1993). "A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins". The Journal of Biological Chemistry. 268 (15): 11050–6. doi:10.1016/S0021-9258(18)82090-7. PMID 8496166.

[entrez-6] "Entrez Gene: PRDX1 peroxiredoxin 1".

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