Peroxisome proliferator-activated receptor delta

PPARD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GWX, 1Y0S, 2AWH, 2B50, 2BAW, 2ENV, 2GWX, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM
Identifiers
Aliases	PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB, peroxisome proliferator activated receptor delta
External IDs	OMIM: 600409; MGI: 101884; HomoloGene: 4544; GeneCards: PPARD; OMA:PPARD - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 35,342,558 bp[1] End 35,428,191 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 14.64 cM Start 28,232,700 bp[2] End 28,301,474 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue skin of thigh tail of epididymis buccal mucosa cell amniotic fluid right lobe of thyroid gland left lobe of thyroid gland corpus epididymis mucosa of transverse colon placenta Top expressed in zygote lip esophagus secondary oocyte interventricular septum muscle of thigh genital tubercle colon granulocyte jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding transcription coactivator activity zinc ion binding metal ion binding steroid hormone receptor activity fatty acid binding protein binding linoleic acid binding protein heterodimerization activity lipid binding DNA-binding transcription factor activity transcription factor binding nuclear receptor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific NF-kappaB binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding nuclear receptor coactivator activity signaling receptor activity Cellular component nucleoplasm nucleus RNA polymerase II transcription regulator complex Biological process fatty acid catabolic process positive regulation of myoblast proliferation positive regulation of epidermis development cell differentiation negative regulation of smooth muscle cell proliferation negative regulation of myoblast differentiation regulation of transcription, DNA-templated placenta development regulation of transcription by RNA polymerase II negative regulation of smooth muscle cell migration wound healing mRNA transcription cholesterol metabolic process negative regulation of apoptotic process response to glucose response to activity response to organic substance generation of precursor metabolites and energy regulation of fat cell differentiation transcription, DNA-templated positive regulation of transcription, DNA-templated response to vitamin A heart development cell-substrate adhesion keratinocyte proliferation positive regulation of gene expression proteoglycan metabolic process regulation of cell population proliferation negative regulation of cell growth fatty acid oxidation positive regulation of cell population proliferation glucose metabolic process phospholipid biosynthetic process negative regulation of epithelial cell proliferation positive regulation of skeletal muscle tissue regeneration apoptotic signaling pathway vitamin A metabolic process positive regulation of phosphatidylinositol 3-kinase signaling keratinocyte migration adipose tissue development transcription initiation from RNA polymerase II promoter regulation of skeletal muscle satellite cell proliferation positive regulation of fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of inflammatory response cellular response to lipopolysaccharide cellular response to hypoxia negative regulation of collagen biosynthetic process positive regulation of insulin secretion steroid hormone mediated signaling pathway apoptotic process cell population proliferation negative regulation of transcription by RNA polymerase II intracellular receptor signaling pathway axon ensheathment decidualization fatty acid transport embryo implantation negative regulation of pri-miRNA transcription by RNA polymerase II lipid metabolism fatty acid beta-oxidation glucose transmembrane transport fatty acid metabolic process multicellular organism development hormone-mediated signaling pathway negative regulation of cholesterol storage regulation of lipid metabolic process response to lipid positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5467 19015 Ensembl ENSG00000112033 ENSMUSG00000002250 UniProt Q03181 P35396 RefSeq (mRNA) NM_001171818 NM_001171819 NM_001171820 NM_006238 NM_177435 NM_011145 RefSeq (protein) NP_001165289 NP_001165290 NP_001165291 NP_006229 NP_803184 NP_035275 Location (UCSC) Chr 6: 35.34 – 35.43 Mb Chr 17: 28.23 – 28.3 Mb PubMed search [3] [4]
Wikidata
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Peroxisome proliferator-activated receptor delta (PPAR-delta), or (PPAR-beta), also known as Nuclear hormone receptor 1 (NUC1) is a nuclear receptor that in humans is encoded by the PPARD gene.^[5]

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. It was first identified in Xenopus in 1993.^[6]