Persister cells

Persister cells are subpopulations of cells that resist treatment, and become antimicrobial tolerant by changing to a state of dormancy or quiescence.[1][2] Persister cells in their dormancy do not divide.[3] The tolerance shown in persister cells differs from antimicrobial resistance in that the tolerance is not inherited and is reversible.[4] When treatment has stopped the state of dormancy can be reversed and the cells can reactivate and multiply. Most persister cells are bacterial, and there are also fungal persister cells,[5] yeast persister cells, and cancer persister cells that show tolerance for cancer drugs.[6]

  1. ^ Van den Bergh, B; Fauvart, M; Michiels, J (1 May 2017). "Formation, physiology, ecology, evolution and clinical importance of bacterial persisters". FEMS Microbiology Reviews. 41 (3): 219–251. doi:10.1093/femsre/fux001. PMID 28333307.
  2. ^ Lewis K (2007). "Persister cells, dormancy and infectious disease". Nature Reviews Microbiology. 5 (1): 48–56. doi:10.1038/nrmicro1557. PMID 17143318. S2CID 6670040.
  3. ^ Brauner, A (2017). "Distinguishing between resistance, tolerance and persistence to antibiotic treatment". Nature Reviews Microbiology. 14 (5): 320–30. doi:10.1038/nrmicro.2016.34. PMID 27080241. S2CID 8308100.
  4. ^ Jayaraman, R (December 2008). "Bacterial persistence: some new insights into an old phenomenon". Journal of Biosciences. 33 (5): 795–805. doi:10.1007/s12038-008-0099-3. PMID 19179767. S2CID 31912576.
  5. ^ Wuyts, J; Van Dijck, P; Holtappels, M (October 2018). "Fungal persister cells: The basis for recalcitrant infections?". PLOS Pathogens. 14 (10): e1007301. doi:10.1371/journal.ppat.1007301. PMC 6193731. PMID 30335865.
  6. ^ Vallette, FM (April 2019). "Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer" (PDF). Biochemical Pharmacology. 162: 169–176. doi:10.1016/j.bcp.2018.11.004. PMID 30414937. S2CID 53285399.