Phillip Allen Sharp

This article is about the American geneticist. For other people, see Philip Sharp.
Phillip Allen Sharp
Sharp with the Winthrop-Sears Medal in 2007
Born (1944-06-06) June 6, 1944 (age 80)
Falmouth, Kentucky, U.S.
Alma mater
Spouse
Ann Holcombe
​
(m. 1964)​
Children3
Awards
Scientific career
FieldsBiologist
Institutions
Doctoral students
Websiteweb.mit.edu/sharplab
External videos
video icon Meet Phillip Sharp: "What we were able to discover was that in human cells and in many other cells of higher-order organisms, the genes come in discontinuous segments", MIT

Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence".[2][3][4][5][6][7] He has been selected to receive the 2015 Othmer Gold Medal.[8]

Sharp's current research focuses on small RNAs and other types of non-coding RNAs. His laboratory works to identify the target mRNAs of microRNAs (miRNAs), and has discovered a class of miRNAs that are produced from sequences adjacent to transcription start sites. His laboratory also studies how miRNA gene regulation functions in angiogenesis and cellular stress.[9][10][11][12]

  1. ^ The Official Site of Louisa Gross Horwitz Prize
  2. ^ "The Nobel Prize in Physiology or Medicine 1993". Nobelprize.org. Nobel Media. Retrieved November 12, 2014.
  3. ^ Sharp, P (2011). "Q&A: Phillip Sharp on biomedical convergence". Cancer Discovery. 1 (5): 370. doi:10.1158/2159-8290.CD-ND11-08. PMID 22586619.
  4. ^ Musgrave, E (2010). "Advancing science across the disciplines: An interview with Nobel Laureate Phillip A. Sharp, PhD". Clinical and Translational Science. 3 (3): 69–70. doi:10.1111/j.1752-8062.2010.00197.x. PMC 5350715. PMID 20590673.
  5. ^ Sharp, P. A.; Sharp, P (2005). "Phillip Sharp discusses RNAi, Nobel Prizes and entrepreneurial science". Drug Discovery Today. 10 (1): 7–10. doi:10.1016/S1359-6446(04)03329-X. PMID 15676292.
  6. ^ Shampo, M. A.; Kyle, R. A. (2004). "Phillip Sharp--Nobel Prize for discovery of "split genes"". Mayo Clinic Proceedings. 79 (6): 727. doi:10.1016/s0025-6196(11)62621-9. PMID 15182083.
  7. ^ Raju, T. N. (2000). "The Nobel chronicles. 1993: Richard John Roberts (b 1943) Phillip a Sharp (b 1944)". Lancet. 355 (9220): 2085. doi:10.1016/s0140-6736(05)73547-9. PMID 10885388. S2CID 53265935.
  8. ^ "Othmer Gold Medal". Science History Institute. Retrieved February 4, 2015.
  9. ^ Autobiography at the Nobel site
  10. ^ Sharp's Research at MIT Archived December 6, 2006, at the Wayback Machine
  11. ^ Thackray, Arnold; Brock, David C.; Ashiya, Mona (November 20, 2003). Phillip A. Sharp, Transcript of Interviews Conducted by Arnold Thackray, David C. Brock, and Mona Ashiya at Massachusetts Institute of Technology Cambridge, Massachusetts on 28 January, 29 May, and 20 November 2003 (PDF). Philadelphia, PA: Chemical Heritage Foundation.
  12. ^ "The Koch Institute: Phillip A. Sharp". ki.mit.edu. Retrieved February 11, 2020.