| Mu-theraphotoxin-Pspp1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | PhlTx1 | ||||||
| UniProt | P0DM14 | ||||||
| |||||||
Phlotoxin (PhlTx1, μ-TRTX-Pspp-1) is a neurotoxin from the venom of the tarantula Phlogiellus that targets mostly voltage-sensitive sodium channels and mainly Nav1.7. The only non-sodium voltage-sensitive channel that is inhibited by Phlotoxin is Kv3.4. Nav1.4 and Nav1.6 seem to be Phlotoxin-1-sensitive to some extent as well.[1]
| Phlotoxin (μ-TRTX-Pspp-1) | |
| Category | Ion channel toxin, Neurotoxin |
|---|---|
| Genus | Phlogiellus |
| Target | voltage-gated sodium channel (mainly) |
| Spider toxin family | NaSpTx-1 |
| Sequence length | 34 amino acids with 3 disulfide bridges |
| Mass | 4058.83 Da |