 Components of phosphatidylserines:
Blue, green: variable fatty acid groups Black: glycerol Red: phosphate Purple: serine | |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane.[1] It plays a key role in cell cycle signaling, specifically in relation to apoptosis. It is a key pathway for viruses to enter cells via apoptotic mimicry.[2] Its exposure on the outer surface of a membrane marks the cell for destruction via apoptosis.[3]
- ^ Kannan, Muthukumar; Riekhof, Wayne R.; Voelker, Dennis R. (2015). "Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast". Traffic. 16 (2): 123–134. doi:10.1111/tra.12236. ISSN 1600-0854. PMID 25355612.
- ^ Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, Lemke G, Schwartz O, Amara A (October 2012). "The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry". Cell Host & Microbe. 12 (4): 544–57. doi:10.1016/j.chom.2012.08.009. PMC 3572209. PMID 23084921.
- ^ Glade, Michael J.; Smith, Kyl (June 2015). "Phosphatidylserine and the human brain". Nutrition. 31 (6): 781–786. doi:10.1016/j.nut.2014.10.014. ISSN 0899-9007.