Phylogenomics

Phylogenomics is the intersection of the fields of evolution and genomics.[1] The term has been used in multiple ways to refer to analysis that involves genome data and evolutionary reconstructions.[2] It is a group of techniques within the larger fields of phylogenetics and genomics. Phylogenomics draws information by comparing entire genomes, or at least large portions of genomes.[3] Phylogenetics compares and analyzes the sequences of single genes, or a small number of genes, as well as many other types of data. Four major areas fall under phylogenomics:

  • Prediction of gene function
  • Establishment and clarification of evolutionary relationships
  • Gene family evolution
  • Prediction and retracing lateral gene transfer.

The ultimate goal of phylogenomics is to reconstruct the evolutionary history of species through their genomes. This history is usually inferred from a series of genomes by using a genome evolution model and standard statistical inference methods (e.g. Bayesian inference or maximum likelihood estimation). [4]

  1. ^ BioMed Central | Fgenerated title -->
  2. ^ Kumar S, Filipski AJ, Battistuzzi FU, Kosakovsky Pond SL, Tamura K (February 2012). "Statistics and truth in phylogenomics". Molecular Biology and Evolution. 29 (2): 457–472. doi:10.1093/molbev/msr202. PMC 3258035. PMID 21873298.
  3. ^ Pennisi E (June 2008). "Evolution. Building the tree of life, genome by genome". Science. 320 (5884): 1716–1717. doi:10.1126/science.320.5884.1716. PMID 18583591. S2CID 206580993.
  4. ^ Simion P, Delsuc F, Phillipe H (2020). "2.1 To What Extent Current Limits of Phylogenomics Can Be Overcome?". Phylogenetics in the Genomic Era. pp. 2.1.1–2.1.34.