Physalaemin
Names
Other names
H-Pyr-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
Identifiers
ChEMBL
MeSH
Physalaemin
UNII
C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@@H]4CCC(=O)N4
Properties
C 58 H 84 N 14 O 16 S
Molar mass
1265 .45 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Physalaemin is a tachykinin peptide obtained from the Physalaemus frog , closely related to substance P . Its structure was first elucidated in 1964.[ 1] [ 2]
Like all tachykinins, physalaemin is a sialagogue (increases salivation ) and a potent vasodilator with hypotensive effects.[ 3]
^ Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus ". Experientia . 20 (9): 489–90. doi :10.1007/BF02154064 . PMID 5857249 . S2CID 25448266 .
^ Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus " . Arch Biochem Biophys . 108 (2): 341–8. doi :10.1016/0003-9861(64)90395-9 . PMID 14240587 .
^ Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family" . Pharmacol Rev . 54 (2): 285–322. doi :10.1124/pr.54.2.285 . PMID 12037144 . S2CID 85570180 .