Pinazepam

Pinazepam
Clinical data
Other names9-chloro-6-phenyl-2-prop-2-ynyl-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismHepatic
ExcretionRenal
Identifiers
  • 7-chloro-5-phenyl-1-prop-2-yn-1-yl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.052.650 Edit this at Wikidata
Chemical and physical data
FormulaC18H13ClN2O
Molar mass308.77 g·mol−1
3D model (JSmol)
  • Clc3cc\1c(N(C(=O)C/N=C/1c2ccccc2)CC#C)cc3
  • InChI=1S/C18H13ClN2O/c1-2-10-21-16-9-8-14(19)11-15(16)18(20-12-17(21)22)13-6-4-3-5-7-13/h1,3-9,11H,10,12H2 checkY
  • Key:MFZOSKPPVCIFMT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pinazepam (marketed under the brand name Domar and Duna) is a benzodiazepine drug.[2] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.[3]

Pinazepam and its metabolite N-desmethyldiazepam are transferred to the developing fetus in utero, but the plasma drug level in the mother is usually significantly higher than in the fetus.[4]

Pinazepam differs from other benzodiazepines in that it has a propargyl group at the N-1 position of the benzodiazepine structure. It is less toxic than diazepam and in animal studies it appears to produce anxiolytic and anti-agitation properties with limited hypnotic and motor coordination impairing properties.[5] Pinazepam is rapidly absorbed after oral administration. The main active metabolites of pinazepam are depropargylpinazepam (N-desmethyldiazepam, nordazepam) and oxazepam.[6] In humans pinazepam acts as a pure anxiolytic agent in that it does not possess to any significant degree the other pharmacological characteristics of benzodiazepines. Its lack of intellectual, motor and hypnotic impairing effects makes it more appropriate than other benzodiazepines for day time use.[7][8][9] The elimination half-life is longer in the elderly.[10]

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Schütz H, Holland EM, Kazemian-Erdmann F, Schölermann K (September 1988). "[Screening of the new benzodiazepine derivative, pinazepan, and its major metabolites]". Arzneimittel-Forschung. 38 (9): 1372–5. PMID 3146986.
  3. ^ Janbroers, J. M. (1984). "Pinazepam: review of pharmacological properties and therapeutic efficacy". Clinical Therapeutics. 6 (4): 434–450. ISSN 0149-2918. PMID 6147192.
  4. ^ Pacifici GM, Cuoci L, Guarneri M, Fornaro P, Arcidiacono G, Cappelli N, et al. (1984). "Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term". European Journal of Clinical Pharmacology. 27 (3): 307–10. doi:10.1007/BF00542165. PMID 6150857. S2CID 1389302.
  5. ^ "Diazepam Injection BP - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Retrieved 2021-08-23.
  6. ^ Dinis-Oliveira, Ricardo Jorge (Sep 14, 2017). "Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects". Drug Metabolism Reviews. 49 (4): 451–463. doi:10.1080/03602532.2017.1377223. ISSN 1097-9883. PMID 28903606. S2CID 4528255.
  7. ^ Janbroers JM (1984). "Pinazepam: review of pharmacological properties and therapeutic efficacy". Clinical Therapeutics. 6 (4): 434–50. PMID 6147192.
  8. ^ Pacifici GM, Placidi GF, Fornaro P, Gomeni R (1983). "Pharmacokinetics of pinazepam in healthy volunteers". International Journal of Clinical Pharmacology Research. 3 (5): 331–7. PMID 6147314.
  9. ^ Pacifici GM, Placidi GF, Fornaro P, Gomeni R (1982). "Pinazepam: a precursor of N-desmethyldiazepam". European Journal of Clinical Pharmacology. 22 (3): 225–8. doi:10.1007/BF00545219. PMID 6809477. S2CID 1977572.
  10. ^ Pacifici GM, Cuoci L, Placidi GF, Fornaro P, Gomeni R (Jan 1982). "Elimination kinetics of desmethyldiazepam in two young and two elderly subjects". European Journal of Drug Metabolism and Pharmacokinetics. 7 (1): 69–72. doi:10.1007/bf03189546. PMID 6802645. S2CID 21836038.