Pinealon

Pinealon
Clinical data
Other namesGlu-Asp-Arg
Identifiers
  • (4S)-4-Amino-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CAS Number
PubChem CID
ChemSpider
ChEBI
Chemical and physical data
FormulaC15H26N6O8
Molar mass418.407 g·mol−1
3D model (JSmol)
  • C(C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)N)CN=C(N)N
  • InChI=1S/C15H26N6O8/c16-7(3-4-10(22)23)12(26)21-9(6-11(24)25)13(27)20-8(14(28)29)2-1-5-19-15(17)18/h7-9H,1-6,16H2,(H,20,27)(H,21,26)(H,22,23)(H,24,25)(H,28,29)(H4,17,18,19)/t7-,8-,9-/m0/s1
  • Key:QPRZKNOOOBWXSU-CIUDSAMLSA-N

Pinealon is a synthetic tripeptide of sequence (Glu-Asp-Arg) and purported geroprotector documented in the Russian scientific literature.[1][2][3][4]

  1. ^ Meshchaninov VN, Tkachenko EL, Zharkov SV, Gavrilov IV, Katyreva I (2015). "Effect of Synthetic Peptides on Aging of Patients with Chronic Polymorbidity and Organic Brain Syndrome of the Central Nervous System in Remission". Advances in Gerontology = Uspekhi Gerontologii. 28 (1): 62–67. PMID 26390612.
  2. ^ Mendzheritskiĭ AM, Karantysh GV, Ivonina KO (2011). "[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats]". Advances in Gerontology = Uspekhi Gerontologii. 24 (1): 74–79. PMID 21809624.
  3. ^ Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A (October 2011). "Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes". Rejuvenation Research. 14 (5): 535–541. doi:10.1089/rej.2011.1172. PMID 21978084.
  4. ^ Kozina LS (2008). "[Investigation of antihypoxic properties of short peptides]". Advances in Gerontology = Uspekhi Gerontologii. 21 (1): 61–67. PMID 18546825.