Piribedil

Piribedil
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • EU: Rx-only[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability10% (peak at 1 hour)
Protein binding70–80%
Metabolismextensive liver
Elimination half-life1.7–6.9 hours
ExcretionKidney (68%) and bile duct (25%)
Identifiers
  • 2-[4-(benzo[1,3]dioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.695 Edit this at Wikidata
Chemical and physical data
FormulaC16H18N4O2
Molar mass298.346 g·mol−1
3D model (JSmol)
  • C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC=CC=N4
  • InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2 ☒N
  • Key:OQDPVLVUJFGPGQ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.[2][3]

  1. ^ "Active substance: piribedil" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 26 November 2020.
  2. ^ Millan MJ, Cussac D, Milligan G, Carr C, Audinot V, Gobert A, et al. (June 2001). "Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization". The Journal of Pharmacology and Experimental Therapeutics. 297 (3): 876–887. PMID 11356907.
  3. ^ Gobert A, Di Cara B, Cistarelli L, Millan MJ (April 2003). "Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors". The Journal of Pharmacology and Experimental Therapeutics. 305 (1): 338–346. doi:10.1124/jpet.102.046383. PMID 12649387. S2CID 29234876.