Plasminogen activator inhibitor-2

SERPINB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ARR, 1BY7, 1JRR, 2ARQ
Identifiers
Aliases	SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2, serpin family B member 2
External IDs	OMIM: 173390; MGI: 97609; HomoloGene: 20571; GeneCards: SERPINB2; OMA:SERPINB2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.33-q22.1 Start 63,871,692 bp[1] End 63,903,888 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E2.1|1 50.34 cM Start 107,439,153 bp[2] End 107,463,208 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid mucosa of pharynx skin of thigh oral cavity skin of hip decidua epithelium of nasopharynx skin of arm islet of Langerhans gums Top expressed in skin of external ear esophagus skin of back lip skin of abdomen granulocyte superior surface of tongue umbilical cord epidermis cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular region plasma membrane extracellular space cytoplasm Biological process negative regulation of peptidase activity wound healing negative regulation of apoptotic process fibrinolysis negative regulation of endopeptidase activity interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5055 18788 Ensembl ENSG00000197632 ENSMUSG00000062345 UniProt P05120 P12388 RefSeq (mRNA) NM_002575 NM_001143818 NM_001174170 NM_011111 RefSeq (protein) NP_001137290 NP_002566 NP_001167641 NP_035241 Location (UCSC) Chr 18: 63.87 – 63.9 Mb Chr 1: 107.44 – 107.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates tissue plasminogen activator and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.

It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.