Polesie or Polesia is a swampy region in the Eastern European Lowland.
Polesie may also refer to the following places in Poland:
- Polesie, Kościan County in Greater Poland Voivodeship (west-central Poland)
- Polesie, Środa Wielkopolska County in Greater Poland Voivodeship (west-central Poland)
- Polesie, Łowicz County in Łódź Voivodeship (central Poland)
- Polesie, Piotrków County in Łódź Voivodeship (central Poland)
- Polesie, Poddębice County in Łódź Voivodeship (central Poland)
- Polesie, Wieruszów County in Łódź Voivodeship (central Poland)
- Polesie, Puławy County in Lublin Voivodeship (east Poland)
- Polesie, Tomaszów Lubelski County in Lublin Voivodeship (east Poland)
- Polesie, Płońsk County in Masovian Voivodeship (east-central Poland)
- Polesie, Opole Voivodeship (south-west Poland)
- Polesie, Pomeranian Voivodeship (north Poland)
- Polesie Voivodeship (1921-1931), administrative unit of interwar Poland