 Skeleton formula of poloxameres, where poloxamer 407 has block lengths of a = 101 and b = 56
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| Names | |
|---|---|
| IUPAC name
Oxirane, methyl-, polymer with oxirane
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Other names
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| Identifiers | |
| DrugBank | |
PubChem CID
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| UNII | |
| Properties | |
| C 572H 1146O 259 | |
| Molar mass | 12,600 g/mol |
| Appearance | white powder |
| Melting point | 53–57 °C (127–135 °F; 326–330 K) |
| very soluble | |
| Hazards | |
| NFPA 704 (fire diamond) | |
| Safety data sheet (SDS) | Kolliphor P 407 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG). The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene glycol block is 56 repeat units.[1] This particular compound is also known by the BASF trade name Pluronic F-127 or by the Croda trade name Synperonic PE/F 127. BASF also offers a pharmaceutical grade, under trade name Kolliphor P 407.[2]
- ^ Tania Betancourt; The University of Texas at Austin. Biomedical Engineering (2007). Targetable biodegradable nanoparticles for delivery of chemotherapeutic and imaging agents to ovarian cancer. pp. 130–. ISBN 978-0-549-34761-3. Retrieved 16 August 2011.
- ^ "Poloxamers for Pharmaceutical Applications". BASF Pharma. Retrieved 2022-06-11.