Polymeric immunoglobulin receptor

PIGR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XED, 2OCW, 3CHN, 3CM9, 5D4K
Identifiers
Aliases	PIGR, Pigr, polymeric immunoglobulin receptor
External IDs	OMIM: 173880; MGI: 103080; HomoloGene: 1984; GeneCards: PIGR; OMA:PIGR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,946,466 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,779,986 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; rectum; ; bronchial epithelial cell; ; duodenum; ; pylorus; ; jejunal mucosa; ; gallbladder; ; olfactory zone of nasal mucosa;
	Top expressed in
	Ileal epithelium; ; left colon; ; crypt of lieberkuhn of small intestine; ; duodenum; ; Paneth cell; ; parotid gland; ; jejunum; ; lacrimal gland; ; left lobe of liver; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	polymeric immunoglobulin receptor activity;
Cellular component	integral component of membrane; extracellular region; receptor complex; integral component of plasma membrane; extracellular exosome; membrane; extracellular space; plasma membrane; azurophil granule membrane;
Biological process	Fc receptor signaling pathway; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; retina homeostasis; detection of chemical stimulus involved in sensory perception of bitter taste; epidermal growth factor receptor signaling pathway; receptor clustering; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5284
	18703
	ENSG00000162896
	ENSMUSG00000026417
	P01833
	O70570
	NM_002644
	NM_011082
	NP_002635
	NP_035212
	Wikidata
View/Edit Human	View/Edit Mouse

Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene.^[5] It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M (pIg) and immune complexes. pIgRs are mainly located on the epithelial lining of mucosal surfaces of the gastrointestinal tract. The composition of the receptor is complex, including 6 immunoglobulin-like domains, a transmembrane region, and an intracellular domain.^[6] pIgR expression is under the strong regulation of cytokines, hormones, and pathogenic stimuli.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162896 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026417 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PIGR polymeric immunoglobulin receptor".
^ ^a ^b Kaetzel CS (August 2005). "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces". Immunological Reviews. 206: 83–99. doi:10.1111/j.0105-2896.2005.00278.x. PMID 16048543. S2CID 43588042.
^ Asano M, Komiyama K (June 2011). "Polymeric immunoglobulin receptor". Journal of Oral Science. 53 (2): 147–156. doi:10.2334/josnusd.53.147. PMID 21712618.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162896 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026417 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez2-5] "Entrez Gene: PIGR polymeric immunoglobulin receptor".

[:0-6] Kaetzel CS (August 2005). "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces". Immunological Reviews. 206: 83–99. doi:10.1111/j.0105-2896.2005.00278.x. PMID 16048543. S2CID 43588042.

[:1-7] Asano M, Komiyama K (June 2011). "Polymeric immunoglobulin receptor". Journal of Oral Science. 53 (2): 147–156. doi:10.2334/josnusd.53.147. PMID 21712618.

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