Polynucleotide adenylyltransferase

polynucleotide adenylyltransferase
Identifiers
EC no.2.7.7.19
CAS no.9026-30-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a polynucleotide adenylyltransferase (EC 2.7.7.19) is an enzyme that catalyzes the chemical reaction

ATP + RNA-3'OH pyrophosphate + RNApA-3'OH
Structure of E. coli poly(A) polymerase based on PDB 3AQN. Missing segments were reconstructed using MODELLER. Rendered using ChimeraX.

Thus, the two substrates of this enzyme are ATP and RNA, whereas its two products are pyrophosphate and RNA with an extra adenosine nucleotide at its 3' end.

Human genes with this activity include TUT1, MTPAP, PAPOLA, PAPOLB, PAPOLG, TENT2, TENT4A, TENT4B, TENT5C, TENT5D.