- 1 September 1854 – The German composer, Engelbert Humperdinck, best known for his opera Hänsel und Gretel, was born in Siegburg.
- 10 September 1659 – Henry Purcell (pictured), the composer of some of the earliest English operas including Dido and Æneas, King Arthur, and The Fairy-Queen, was born in London.
- 14 September 1872 – The Teatro Dal Verme opened in Milan. The theatre saw the world premieres of Puccini's Le Villi in 1884 and Leoncavallo's Pagliacci in 1892.
- 16 September 1977 – The celebrated Greek soprano, Maria Callas, died in Paris at the age of 53.
- 23 September 1835 – The Italian bel canto composer Vincenzo Bellini, whose operas include La sonnambula, I puritani, and Norma, died in Paris at the age of 33.
- 25 September 1886 – Alfred Cellier's comic opera Dorothy premiered at London's Gaiety Theatre with Marion Hood in the title role.
- 28 September 1968 – The prominent Spanish tenor, Plácido Domingo, made his Metropolitan Opera debut when he substituted for Franco Corelli in Cilea's Adriana Lecouvreur.
- 30 September 1791 – Mozart's opera The Magic Flute received its world premiere at the Theater auf der Wieden in Vienna.