Poser criteria

Poser criteria
PurposeDiagnostic criteria for multiple sclerosis

Poser criteria are diagnostic criteria for multiple sclerosis (MS). They replaced the older Schumacher criteria,[1] and are now considered obsolete as McDonald criteria have superseded them. Nevertheless, some of the concepts introduced have remained in MS research, like CDMS (clinical definite MS), and newer criteria are often calibrated against them.[2] The criteria were unveiled in the Annals of Neurology in 1983 by a team led by Dr. Charles M. Poser.[3]

The article that introduced them also defined the concepts of attack, historical information, clinical evidence, paraclinical evidence, lesion typical of MS, remission, separate lesions and laboratory support, which are necessary to apply the criteria.[citation needed]

The criteria considers MS as the presence of demyelinating lesions disseminated in time and space, and they are oriented specially to prove the dissemination. Based on this, the authors defined a set of rules that can yield five conclusions:[3] CDMS, LSDMS, CPMS, LSPMS or noMS. Poser diagnosis of CDMS is known to have a sensitivity of 87% respect postmortem autopsy examination[4]

  1. ^ Schumacher GA, Beebe G, Kibler RF, Kurland LT, Kurtzke JF, McDowell F, Nagler B, Sibley WA, Tourtellotte WW, Willmon TL (March 1965). "Problems of Experimental Trials of Therapy in Multiple Sclerosis: Report by the Panel on the Evaluation of Experimental Trials of Therapy in Multiple Sclerosis". Ann N Y Acad Sci. 122 (1): 552–568. Bibcode:1965NYASA.122..552S. doi:10.1111/j.1749-6632.1965.tb20235.x. PMID 14313512. S2CID 20718640.
  2. ^ Christopher J. Lisanti, Patrick Asbach, and William G. Bradley, Jr. The Ependymal "Dot-Dash" Sign: An MR Imaging Finding of Early Multiple Sclerosis, AJNR Am J Neuroradiol 26:2033–2036, September 2005
  3. ^ a b Poser CM, Paty DW, Scheinberg L, et al. (March 1983). "New diagnostic criteria for multiple sclerosis: Guidelines for research protocols" (PDF). Annals of Neurology. 13 (3): 227–31. doi:10.1002/ana.410130302. PMID 6847134. S2CID 42781540. Archived from the original (PDF) on 2010-03-24. Retrieved 2009-11-05.
  4. ^ Izquierdo G, Hauw J-J, Lyon-Caen O; et al. (1985). "Value of multiple sclerosis diagnostic criteria: 70 Autopsy-confirmed cases". Arch Neurol. 42 (9): 848–850. doi:10.1001/archneur.1985.04060080026010. PMID 4026627.{{cite journal}}: CS1 maint: multiple names: authors list (link)