Position-effect variegation

Position-effect variegation (PEV) is a variegation caused by the silencing of a gene in some cells through its abnormal juxtaposition with heterochromatin via rearrangement or transposition.[1] It is also associated with changes in chromatin conformation.[2]

  1. ^ Elgin, Sarah C.R.; Reuter, Gunter (August 2013). "Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila". Cold Spring Harbor Perspectives in Biology. 5 (8): a017780. doi:10.1101/cshperspect.a017780. ISSN 1943-0264. PMC 3721279. PMID 23906716.
  2. ^ Lloyd, Vett K.; Sinclair, Don A.; Grigliatti, Thomas A. (1999-04-01). "Genomic Imprinting and Position-Effect Variegation in Drosophila melanogaster". Genetics. 151 (4): 1503–1516. doi:10.1093/genetics/151.4.1503. ISSN 0016-6731. PMC 1460573. PMID 10101173.