Prazosin

Prazosin
prazosin 2D skeletal
prazosin 3D BS
Clinical data
Trade namesMinipress, others
AHFS/Drugs.comMonograph
MedlinePlusa682245
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classα1 blocker
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability~60%
Protein binding97%[4]
Onset of action30–90 minutes[5]
Elimination half-life2–3 hours[4]
Duration of action10–24 hours[4]
Identifiers
  • [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.038.971 Edit this at Wikidata
Chemical and physical data
FormulaC19H21N5O4
Molar mass383.408 g·mol−1
3D model (JSmol)
  • O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)c4occc4
  • InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) checkY
  • Key:IENZQIKPVFGBNW-UHFFFAOYSA-N checkY
  (verify)

Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares related to post-traumatic stress disorder (PTSD).[6] It is an α1 blocker.[6] It is a less preferred treatment of high blood pressure.[6] Other uses may include heart failure and Raynaud syndrome.[7] It is taken by mouth.[6]

Common side effects include dizziness, sleepiness, nausea, and heart palpitations.[6] Serious side effects may include low blood pressure with standing and depression.[6][7] Prazosin is a non-selective inverse agonist of the α1-adrenergic receptors.[6] It works to decrease blood pressure by dilating blood vessels and helps with an enlarged prostate by relaxing the outflow of the bladder.[6] How it works in PTSD is not entirely clear.[6]

Prazosin was patented in 1965 and came into medical use in 1974.[8] It is available as a generic medication.[6] In 2021, it was the 183rd most commonly prescribed medication in the United States, with more than 2 million prescriptions.[9][10]

  1. ^ "Prazosin (Minipress) Use During Pregnancy". Drugs.com. 26 November 2019. Retrieved 30 January 2020.
  2. ^ "Hypovase Tablets 0.5mg - Summary of Product Characteristics (SmPC)". (emc). 26 April 2021. Retrieved 5 February 2023.
  3. ^ "Minipress- prazosin hydrochloride capsule". DailyMed. 19 July 2021. Retrieved 5 February 2023.
  4. ^ a b c "Prazosin". drugs.com. Retrieved 15 March 2020.
  5. ^ Packer M, Meller J, Gorlin R, Herman MV (March 1979). "Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure". Circulation. 59 (3): 531–539. doi:10.1161/01.cir.59.3.531. PMID 761333.
  6. ^ a b c d e f g h i j "Prazosin Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.
  7. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 766. ISBN 9780857113382.
  8. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 455. ISBN 9783527607495.
  9. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  10. ^ "Prazosin - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.