Pregnancy-associated malaria

Pregnancy-associated malaria (PAM) or placental malaria is a presentation of malaria in pregnancy which is life-threatening to both pregnant women and unborn fetuses.[1] PAM occurs when a pregnant woman contracts malaria, generally as a result of Plasmodium falciparum infection, and because she is pregnant, is at greater risk of associated complications such as placental malaria. [1][2][3][4] Placental malaria interferes with the transmission of vital substances through the fetal placenta, which can result in stillbirths, miscarriages, and dangerously low birth weights.[5] [6][7]

Prevention and treatment of malaria are essential components of prenatal care in tropical and subtropical geographic areas affected by malaria, and thus has received much international attention.[8][9]

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  6. ^ Srivastava A, Gangnard S, Round A, Dechavanne S, Juillerat A, Raynal B, et al. (March 2010). "Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA". Proceedings of the National Academy of Sciences of the United States of America. 107 (11): 4884–9. Bibcode:2010PNAS..107.4884S. doi:10.1073/pnas.1000951107. PMC 2841952. PMID 20194779.
  7. ^ Matteelli A, Caligaris S, Castelli F, Carosi G (October 1997). "The placenta and malaria". Annals of Tropical Medicine and Parasitology. 91 (7): 803–10. doi:10.1080/00034989760563. PMID 9625937.
  8. ^ Duffy PE, Fried M (2005). "Malaria in the Pregnant Woman". Malaria: Drugs, Disease and Post-genomic Biology. Current Topics in Microbiology and Immunology. Vol. 295. pp. 169–200. doi:10.1007/3-540-29088-5_7. ISBN 978-3-540-25363-1. PMID 16265891.
  9. ^ "Roll Back Malaria: Malaria in Pregnancy". WHO. Archived from the original on 6 August 2006. Retrieved 18 April 2011.