Pregnancy-specific beta-1-glycoprotein 1

PSG1
Identifiers
Aliases	PSG1, B1G1, CD66f, DHFRP2, FL-NCA-1/2, PBG1, PS-beta-C/D, PS-beta-G-1, PSBG-1, PSBG1, PSG95, PSGGA, PSGIIA, SP1, pregnancy specific beta-1-glycoprotein 1
External IDs	OMIM: 176390; HomoloGene: 136364; GeneCards: PSG1; OMA:PSG1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,879,822 bp
RNA expression pattern
	Top expressed in
	placenta; ; buccal mucosa cell; ; testicle; ; stromal cell of endometrium; ; amniotic fluid; ; gonad; ; pancreatic ductal cell; ; secondary oocyte; ; skin of hip; ; lower lobe of lung;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region;
Biological process	female pregnancy; leukocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	5669
	n/a
	ENSG00000231924
	n/a
	P11464
	n/a
	NM_001184825; NM_001184826; NM_001297773; NM_006905; NM_001330524
	n/a
	NP_001171754; NP_001171755; NP_001284702; NP_001317453; NP_008836
	n/a
	Wikidata
View/Edit Human

Pregnancy-specific beta-1-glycoprotein 1 (PSBG-1) also known as CD66f (Cluster of Differentiation 66f), is a protein that in humans is encoded by the PSG1 gene and is a member of the carcinoembryonic antigen (CEA) gene family.^[3] Pregnancy-specific glycoproteins (PSGs) are a complex consisting of carbohydrate and protein, which is present in the mammalian body specifically during pregnancy. This glycoprotein is the most abundant protein found in the maternal bloodstream during the later stages of pregnancy^[4] and it is of vital importance in fetal development.^[5] The PSG functions primarily as an immunomodulator to protect the growing fetus.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000231924 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PSG1 pregnancy specific beta-1-glycoprotein 1".
^ McLellan AS, Fischer B, Dveksler G, Hori T, Wynne F, Ball M, Okumura K, Moore T, Zimmermann W (2005). "Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus". BMC Genomics. 6: 4. doi:10.1186/1471-2164-6-4. PMC 546212. PMID 15647114.
^ Gray-Owen SD, Blumberg RS (June 2006). "CEACAM1: contact-dependent control of immunity". Nat. Rev. Immunol. 6 (6): 433–46. doi:10.1038/nri1864. PMID 16724098. S2CID 34156579.
^ Lisboa FA, Warren J, Sulkowski G, Aparicio M, David G, Zudaire E, Dveksler GS (March 2011). "Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans". J. Biol. Chem. 286 (9): 7577–86. doi:10.1074/jbc.M110.161810. PMC 3045012. PMID 21193412.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000231924 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: PSG1 pregnancy specific beta-1-glycoprotein 1".

[mcLellen-4] McLellan AS, Fischer B, Dveksler G, Hori T, Wynne F, Ball M, Okumura K, Moore T, Zimmermann W (2005). "Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus". BMC Genomics. 6: 4. doi:10.1186/1471-2164-6-4. PMC 546212. PMID 15647114.

[gray-owen-5] Gray-Owen SD, Blumberg RS (June 2006). "CEACAM1: contact-dependent control of immunity". Nat. Rev. Immunol. 6 (6): 433–46. doi:10.1038/nri1864. PMID 16724098. S2CID 34156579.

[lisboa-6] Lisboa FA, Warren J, Sulkowski G, Aparicio M, David G, Zudaire E, Dveksler GS (March 2011). "Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans". J. Biol. Chem. 286 (9): 7577–86. doi:10.1074/jbc.M110.161810. PMC 3045012. PMID 21193412.

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