Prehistory of Ohio provides an overview of the activities that occurred prior to Ohio's recorded history. The ancient hunters, Paleo-Indians (13000 B.C. to 7000 B.C.), descended from humans that crossed the Bering Strait. There is evidence of Paleo-Indians in Ohio, who were hunter-gatherers that ranged widely over land to hunt large game. For instance, mastodon bones were found at the Burning Tree Mastodon site that showed that it had been butchered. Clovis points have been found that indicate interaction with other groups and hunted large game. The Paleo Crossing site and Nobles Pond site provide evidence that groups interacted with one another. The Paleo-Indian's diet included fish, small game, and nuts and berries that gathered. They lived in simple shelters made of wood and bark or hides. Canoes were created by digging out trees with granite axes.
The weather warmed and forest grew more dense with next period of the Archaic people (8000 B.C. to 500 B.C.). Although they were also hunter-gatherers, they did not travel as far for food and began to live longer periods of time in one place. They dug pits to store food and built studier lodging. Tools, like spear-throwers, were more sophisticated. Base camps were established for winter lodging. The Glacial Kame culture, a late Archaic group, traded for sea shell and copper with other groups and were used as a sign of prestige within the group, for respected healers and hunters. The objects were buried with their owners. By the Woodland period (800 B.C. to A.D. 1200) of the Post-Archaic Period, people lived in villages, developed a rich ritual and artistic life, began building earthworks and mounds, some of which were used for burial. While they still hunted and gathered food, they cultivated crops. The Adena and Hopewell cultures flourished during the Early and Middle Woodland periods, respectively. The population of Woodland people expanded dramatically and groups lived in larger villages with defensive walls or ditches built for protection. Ritual and artistic endeavors waned during the Late Woodland period, as did trading with other groups. There were not new earthworks or mounds during this later period.
During the late prehistoric period (A.D. 900 to 1650), villages were larger, often built on high ground, near a river, and often surrounded by a wooden stockade. Earthworks returned during this period, but were not built in the frequency that they were during the Woodland period. The Serpent Mound, the country's largest effigy mound, was created by the Fort Ancient culture. Maize became a staple of their diet, while squash and beans were cultivated. The centers of villages were the locations where ceremonial rituals were conducted.
The Early Contact period (1600–1750) began when Ohio tribes met Europeans, but they had begun to acquire European trade items in as much as a hundred years before they met through trade with other Native American groups. They traded for glass beads, brass, and copper items. Direct contact began in the late 17th century when traders, white explorers, and settlers came to Ohio. With them came smallpox which devastated Native American tribes, particularly affecting children and the elderly.