Procarbazine

Procarbazine
Clinical data
Trade namesMatulane, Natulan, Indicarb, others
AHFS/Drugs.comMonograph
MedlinePlusa682094
Pregnancy
category
  • AU: D
Routes of
administration		By mouth (gel capsule), intravenous
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolismliver, kidney
Elimination half-life10 minutes
Excretionkidney
Identifiers
  • N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.010.531 Edit this at Wikidata
Chemical and physical data
FormulaC12H19N3O
Molar mass221.304 g·mol−1
3D model (JSmol)
  • O=C(c1ccc(cc1)CNNC)NC(C)C
  • InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16) checkY
  • Key:CPTBDICYNRMXFX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers.[1] For Hodgkin's it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine.[1] It is typically taken by mouth.[1]

Common side effect include low blood cell counts and vomiting.[1] Other side effects include tiredness and depression.[2][3] It is not recommended in people with severe liver or kidney problems.[4] Use in pregnancy is known to harm the baby.[1] Procarbazine is in the alkylating agents family of medication.[1] How it works is not clearly known.[1]

Procarbazine was approved for medical use in the United States in 1969.[1] It is on the World Health Organization's List of Essential Medicines.[5][6] In the United Kingdom a month of treatment cost the National Health Service 450 to 750 pounds.[4]

  1. ^ a b c d e f g h "Procarbazine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
  2. ^ "Procarbazine Capsules 50mg – Summary of Product Characteristics". UK Electronic Medicines Compendium. 24 November 2014. Archived from the original on 20 December 2016.
  3. ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 228. hdl:10665/44053. ISBN 9789241547659.
  4. ^ a b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 606. ISBN 9780857111562.
  5. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.