Proliferative index

Proliferation, as one of the hallmarks and most fundamental biological processes in tumors,[1] is associated with tumor progression, response to therapy, and cancer patient survival.[2] Consequently, the evaluation of a tumor proliferative index (or growth fraction) has clinical significance in characterizing many solid tumors and hematologic malignancies.[3] This has led investigators to develop different technologies to evaluate the proliferation index in tumor samples. The most commonly used methods in evaluating a proliferative index include mitotic indexing, thymidine-labeling index, bromodeoxyuridine assay, the determination of fraction of cells in various phases of cell cycle, and the immunohistochemical evaluation of cell cycle-associated proteins.

  1. ^ Hanahan, Douglas; Weinberg, Robert A. (2011). "Hallmarks of Cancer: The Next Generation". Cell. 144 (5): 646–674. doi:10.1016/j.cell.2011.02.013. PMID 21376230.
  2. ^ Yerushalmi, Rinat; Woods, Ryan; Ravdin, Peter M; Hayes, Malcolm M; Gelmon, Karen A (February 2010). "Ki67 in breast cancer: prognostic and predictive potential". The Lancet Oncology. 11 (2): 174–183. doi:10.1016/s1470-2045(09)70262-1. PMID 20152769.
  3. ^ Loo, Suet Kee; Ch'ng, Ewe Seng; Lawrie, Charles H.; Muruzabal, María Arestin; Gaafar, Ayman; Pomposo, María Puente; Husin, Azlan; Salleh, Md. Salzihan Md.; Banham, Alison H. (December 2017). "DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas". Pathology. 49 (7): 731–739. doi:10.1016/j.pathol.2017.08.009. PMID 29074044.