Properdin

CFP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W0R, 1W0S
Identifiers
Aliases	CFP, BFD, PFC, PFD, PROPERDIN, complement factor properdin, properdin
External IDs	OMIM: 300383; MGI: 97545; HomoloGene: 1969; GeneCards: CFP; OMA:CFP - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 47,623,172 bp[1] End 47,630,305 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.3|X 16.44 cM Start 20,791,693 bp[2] End 20,797,794 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen bone marrow bone marrow cells gonad appendix lymph node right lung Top expressed in granulocyte stroma of bone marrow spleen mesenteric lymph nodes ankle joint right lobe of liver axillary lymph node white adipose tissue tibiofemoral joint thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding serine-type endopeptidase activity Cellular component extracellular matrix endoplasmic reticulum lumen extracellular region extracellular space specific granule lumen tertiary granule lumen collagen-containing extracellular matrix Biological process immune response regulation of complement activation defense response to bacterium immune system process complement activation protein O-linked fucosylation complement activation, alternative pathway innate immune response neutrophil degranulation proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5199 18636 Ensembl ENSG00000126759 ENSMUSG00000001128 UniProt P27918 P11680 RefSeq (mRNA) NM_002621 NM_001145252 NM_008823 RefSeq (protein) NP_001138724 NP_002612 NP_032849 Location (UCSC) Chr X: 47.62 – 47.63 Mb Chr X: 20.79 – 20.8 Mb PubMed search [3] [4]
Wikidata
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Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.

Properdin is plasma glycoprotein that activates the complement system of the innate immune system. This protein binds to bacterial cell walls and dying human cells to stabilize the C3 and C5-convertase enzyme complexes to form an attack complex that lead to the lysis of the cell.