Proprotein convertase 1

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proprotein convertase 1
proprotein convertase 1
Identifiers
EC no.	3.4.21.93
CAS no.	99676-46-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

PCSK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KN6, 2KDT, 2KE3
Identifiers
Aliases	PCSK1, BMIQ12, NEC1, PC1, PC3, SPC3, proprotein convertase subtilisin/kexin type 1, PC1/3, PCSK1 gene
External IDs	OMIM: 162150; MGI: 97511; HomoloGene: 379; GeneCards: PCSK1; OMA:PCSK1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	96,434,143 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	75,282,980 bp
RNA expression pattern
	Top expressed in
	beta cell; ; postcentral gyrus; ; superior frontal gyrus; ; orbitofrontal cortex; ; Brodmann area 23; ; Brodmann area 46; ; endothelial cell; ; Brodmann area 10; ; primary visual cortex; ; testicle;
	Top expressed in
	supraoptic nucleus; ; islet of Langerhans; ; pars distalis of adenohypophysis; ; lumbar spinal ganglion; ; dentate gyrus of hippocampal formation granule cell; ; paraventricular nucleus of hypothalamus; ; primary visual cortex; ; superior frontal gyrus; ; arcuate nucleus; ; central gray substance of midbrain;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; endopeptidase activity; hydrolase activity; serine-type endopeptidase activity; identical protein binding;
Cellular component	secretory granule lumen; transport vesicle; cytoplasmic vesicle; extracellular space; membrane; neuron projection;
Biological process	peptide biosynthetic process; cell-cell signaling; peptide hormone processing; proteolysis; protein processing;
	Sources:Amigo / QuickGO
Orthologs
	5122
	18548
	ENSG00000175426
	ENSMUSG00000021587
	P29120
	P63239
	NM_001177876; NM_000439; NM_001177875
	NM_013628
	NP_000430; NP_001171346
	NP_038656
	Wikidata
View/Edit Human	View/Edit Mouse

Proprotein convertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is an enzyme that in humans is encoded by the PCSK1 gene.^[5] PCSK1 and PCSK2 differentially cleave proopiomelanocortin and they act together to process proinsulin and proglucagon in pancreatic islets.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175426 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021587 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seidah NG, Mattei MG, Gaspar L, Benjannet S, Mbikay M, Chrétien M (September 1991). "Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region)". Genomics. 11 (1): 103–7. doi:10.1016/0888-7543(91)90106-O. PMID 1765368.
^ Jansen E, Ayoubi TA, Meulemans SM, Van de Ven WJ (June 1995). "Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements". J. Biol. Chem. 270 (25): 15391–7. doi:10.1074/jbc.270.25.15391. PMID 7797529.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175426 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021587 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1765368-5] Seidah NG, Mattei MG, Gaspar L, Benjannet S, Mbikay M, Chrétien M (September 1991). "Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region)". Genomics. 11 (1): 103–7. doi:10.1016/0888-7543(91)90106-O. PMID 1765368.

[pmid7797529-6] Jansen E, Ayoubi TA, Meulemans SM, Van de Ven WJ (June 1995). "Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements". J. Biol. Chem. 270 (25): 15391–7. doi:10.1074/jbc.270.25.15391. PMID 7797529.

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