Propylhexedrine

Propylhexedrine
Clinical data
Trade names	Benzedrex, Obesin, Dristan Inhaler, and others
Other names	Hexahydrodesoxyephedrine; Cyclohexylisopropylmethylamine; 1-cyclohexyl-2-methylaminopropane;
AHFS/Drugs.com	Monograph
Pregnancy; category	C;
Routes of; administration	Medical: Intranasal (inhaler); Recreational: Oral, parenteral
ATC code	N06BA ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class B1 (Psychoactive drugs); CA: Unscheduled; DE: Prescription Only; UK: P (Pharmacy medicines); US: OTC; UN: Unscheduled;
Pharmacokinetic data
Elimination half-life	4 ± 1.5 hours
Identifiers
	IUPAC name (±)-1-cyclohexyl-N-methylpropan-2-amine;
CAS Number	101-40-6 ; hydrochloride: 1007-33-6 ;
PubChem CID	7558;
DrugBank	DB06714 ;
ChemSpider	7277 ;
UNII	LQU92IU8LL; hydrochloride: 064LUN7NZ5 ;
KEGG	D05637 ;
CompTox Dashboard (EPA)	DTXSID1023526 ;
ECHA InfoCard	100.002.673
Chemical and physical data
Formula	C10H21N
Molar mass	155.285 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES N(C(CC1CCCCC1)C)C;
	InChI InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3 ; Key:JCRIVQIOJSSCQD-UHFFFAOYSA-N ;
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Propylhexedrine, sold under the brand name Benzedrex among others, is an alkylamine primarily utilized as a topical nasal decongestant.^[1] Its main indications are relief of congestion due to colds, allergies, and allergic rhinitis.^[2] Propylhexedrine was first used medically in 1949, with the release of Benzedrex by Smith, Kline & French, and it has been used, mainly within the United States, since then.^[3]

^ "Cold, Cough, Allergy, Bronchodilator, and Antiasthmatic Drug Products for Over-the-Counter Human Use". FDA. 7 June 2023. Archived from the original on 6 July 2023. Retrieved 5 July 2023.
^ "BENZEDREX 09-19-2014- propylhexedrine inhalant". Daily Med. U.S. National Library of Medicine. Archived from the original on 16 July 2023. Retrieved 15 July 2023.
^ Cite error: The named reference Schwarez was invoked but never defined (see the help page).

[1] "Cold, Cough, Allergy, Bronchodilator, and Antiasthmatic Drug Products for Over-the-Counter Human Use". FDA. 7 June 2023. Archived from the original on 6 July 2023. Retrieved 5 July 2023.

[Daily_Med-2] "BENZEDREX 09-19-2014- propylhexedrine inhalant". Daily Med. U.S. National Library of Medicine. Archived from the original on 16 July 2023. Retrieved 15 July 2023.

[Schwarez-3] Cite error: The named reference Schwarez was invoked but never defined (see the help page).

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