Protease-activated receptor 2

F2RL1
Identifiers
Aliases	F2RL1, GPR11, PAR2, Protease activated receptor 2, F2R like trypsin receptor 1
External IDs	OMIM: 600933; MGI: 101910; HomoloGene: 21087; GeneCards: F2RL1; OMA:F2RL1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 76,818,933 bp[1] End 76,835,315 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 49.53 cM Start 95,648,240 bp[2] End 95,661,735 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon jejunal mucosa skin of thigh duodenum kidney tubule rectum skin of hip gingival epithelium mucosa of ileum mucosa of transverse colon Top expressed in epithelium of stomach vestibular membrane of cochlear duct left colon pineal gland ileum corneal stroma mucous cell of stomach pyloric antrum jejunum lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity thrombin-activated receptor activity G-protein beta-subunit binding protein binding G-protein alpha-subunit binding signaling receptor binding signaling receptor activity Cellular component integral component of membrane Golgi apparatus pseudopodium membrane plasma membrane integral component of plasma membrane early endosome Biological process positive regulation of Rho protein signal transduction establishment of endothelial barrier thrombin-activated receptor signaling pathway neutrophil activation positive regulation of phagocytosis, engulfment positive regulation of toll-like receptor 3 signaling pathway positive regulation of eosinophil degranulation positive regulation of neutrophil mediated killing of gram-negative bacterium negative regulation of tumor necrosis factor-mediated signaling pathway immune system process positive regulation of cell migration positive regulation of cytosolic calcium ion concentration blood coagulation positive regulation of JNK cascade positive regulation of leukocyte chemotaxis negative regulation of JNK cascade leukocyte proliferation regulation of JNK cascade positive regulation of pseudopodium assembly positive regulation of renin secretion into blood stream defense response to virus positive regulation of chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of toll-like receptor 2 signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of superoxide anion generation positive regulation of glomerular filtration regulation of blood coagulation inflammatory response innate immune response mature conventional dendritic cell differentiation negative regulation of toll-like receptor 3 signaling pathway positive regulation of actin filament depolymerization leukocyte migration regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription by RNA polymerase II positive regulation of positive chemotaxis signal transduction T cell activation involved in immune response positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway positive regulation of GTPase activity cell-cell junction maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2150 14063 Ensembl ENSG00000164251 ENSMUSG00000021678 UniProt P55085 P55086 RefSeq (mRNA) NM_005242 NM_007974 RefSeq (protein) NP_005233 NP_032000 Location (UCSC) Chr 5: 76.82 – 76.84 Mb Chr 13: 95.65 – 95.66 Mb PubMed search [3] [4]
Wikidata
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Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11) is a protein that in humans is encoded by the F2RL1 gene. PAR2 modulates inflammatory responses,^[5] obesity,^[6] metabolism,^[7] cancers ^[8][9] and acts as a sensor for proteolytic enzymes generated during infection.^[10] In humans, we can find PAR2 in the stratum granulosum layer of epidermal keratinocytes. Functional PAR2 is also expressed by several immune cells such as eosinophils, neutrophils, monocytes, macrophages, dendritic cells, mast cells and T cells.^[11]