Protein-coding gene in the species Homo sapiens
OGT |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1W3B, 3PE3, 3PE4, 3TAX, 4AY5, 4AY6, 4CDR, 4GYW, 4GYY, 4GZ3, 4GZ5, 4GZ6, 4N39, 4N3A, 4N3B, 4XI9, 4XIF, 5BNW, 5C1D |
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Identifiers |
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Aliases | OGT, HRNT1, O-GLCNAC, HINCUT-1, O-linked N-acetylglucosamine (GlcNAc) transferase, OGT1, MRX106, XLID106 |
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External IDs | OMIM: 300255; MGI: 1339639; HomoloGene: 9675; GeneCards: OGT; OMA:OGT - orthologs |
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Wikidata |
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Protein O-GlcNAc transferase also known as OGT or O-linked N-acetylglucosaminyltransferase is an enzyme (EC 2.4.1.255) that in humans is encoded by the OGT gene.[5][6] OGT catalyzes the addition of the O-GlcNAc post-translational modification to proteins.[7][8][9][10][5][11]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000147162 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034160 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Lubas WA, Frank DW, Krause M, Hanover JA (April 1997). "O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats". The Journal of Biological Chemistry. 272 (14): 9316–24. doi:10.1074/jbc.272.14.9316. PMID 9083068.
- ^ "Entrez Gene: OGT O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)".
- ^ Banerjee S, Robbins PW, Samuelson J (April 2009). "Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum". Glycobiology. 19 (4): 331–6. doi:10.1093/glycob/cwn107. PMC 2733775. PMID 18948359.
- ^ Clarke AJ, Hurtado-Guerrero R, Pathak S, Schüttelkopf AW, Borodkin V, Shepherd SM, et al. (October 2008). "Structural insights into mechanism and specificity of O-GlcNAc transferase". The EMBO Journal. 27 (20): 2780–8. doi:10.1038/emboj.2008.186. PMC 2556091. PMID 18818698.
- ^ Rao FV, Dorfmueller HC, Villa F, Allwood M, Eggleston IM, van Aalten DM (April 2006). "Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis". The EMBO Journal. 25 (7): 1569–78. doi:10.1038/sj.emboj.7601026. PMC 1440316. PMID 16541109.
- ^ Haltiwanger RS, Blomberg MA, Hart GW (May 1992). "Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase". The Journal of Biological Chemistry. 267 (13): 9005–13. doi:10.1016/S0021-9258(19)50380-5. PMID 1533623.
- ^ Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S (January 2011). "Structure of human O-GlcNAc transferase and its complex with a peptide substrate". Nature. 469 (7331): 564–7. Bibcode:2011Natur.469..564L. doi:10.1038/nature09638. PMC 3064491. PMID 21240259.