Protein Z

PROZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3F1S
Identifiers
Aliases	PROZ, PZ, Protein Z, protein Z, vitamin K dependent plasma glycoprotein
External IDs	OMIM: 176895; MGI: 1860488; HomoloGene: 2890; GeneCards: PROZ; OMA:PROZ - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	113,172,386 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,126,026 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; mucosa of transverse colon; ; right testis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; pituitary gland;
	Top expressed in
	liver; ; left lobe of liver; ; yolk sac; ; granulocyte; ; epithelium of small intestine; ; right kidney; ; duodenum; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; serine-type endopeptidase activity;
Cellular component	Golgi lumen; extracellular region; endoplasmic reticulum lumen; extracellular exosome; extracellular space;
Biological process	hemostasis; endoplasmic reticulum to Golgi vesicle-mediated transport; peptidyl-glutamic acid carboxylation; signal peptide processing; proteolysis; blood coagulation; negative regulation of blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	8858
	66901
	ENSG00000126231
	ENSMUSG00000031445
	P22891
	Q9CQW3
	NM_001256134; NM_003891
	NM_025834; NM_001357219; NM_001357220
	NP_001243063; NP_003882
	NP_080110; NP_001344148; NP_001344149
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Z (PZ or PROZ), vitamin K-dependent protein Z, is a protein encoded in the human by the PROZ gene.^[5]^[6]

Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is a glycoprotein. Protein Z functions to inhibit blood coagulation by binding to an inhibitor.^[7] It is a GLA domain protein and thus Vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126231 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031445 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ichinose A, Takeya H, Espling E, Iwanaga S, Kisiel W, Davie EW (November 1990). "Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein". Biochemical and Biophysical Research Communications. 172 (3): 1139–1144. doi:10.1016/0006-291X(90)91566-B. PMID 2244898.
^ Sejima H, Hayashi T, Deyashiki Y, Nishioka J, Suzuki K (September 1990). "Primary structure of vitamin K-dependent human protein Z". Biochemical and Biophysical Research Communications. 171 (2): 661–668. doi:10.1016/0006-291X(90)91197-Z. PMID 2403355.
^ Wei Z, Yan Y, Carrell RW, Zhou A (October 2009). "Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X". Blood. 114 (17): 3662–3667. doi:10.1182/blood-2009-04-210021. PMC 2766681. PMID 19528533.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126231 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031445 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2244898-5] Ichinose A, Takeya H, Espling E, Iwanaga S, Kisiel W, Davie EW (November 1990). "Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein". Biochemical and Biophysical Research Communications. 172 (3): 1139–1144. doi:10.1016/0006-291X(90)91566-B. PMID 2244898.

[pmid2403355-6] Sejima H, Hayashi T, Deyashiki Y, Nishioka J, Suzuki K (September 1990). "Primary structure of vitamin K-dependent human protein Z". Biochemical and Biophysical Research Communications. 171 (2): 661–668. doi:10.1016/0006-291X(90)91197-Z. PMID 2403355.

[7] Wei Z, Yan Y, Carrell RW, Zhou A (October 2009). "Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X". Blood. 114 (17): 3662–3667. doi:10.1182/blood-2009-04-210021. PMC 2766681. PMID 19528533.

[1]

[2]

[3]

[4]

[5]

[6]

[7]