Proteinase 3

PRTN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FUJ
Identifiers
Aliases	PRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3
External IDs	OMIM: 177020; MGI: 893580; HomoloGene: 120934; GeneCards: PRTN3; OMA:PRTN3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	848,175 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,719,008 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; spleen; ; blood; ; monocyte; ; granulocyte; ; right lung; ; superior frontal gyrus; ; right frontal lobe; ; dorsolateral prefrontal cortex;
	Top expressed in
	tibiofemoral joint; ; granulocyte; ; fetal liver hematopoietic progenitor cell; ; body of femur; ; bone marrow; ; ankle joint; ; blastocyst; ; embryo; ; human fetus; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding; peptidase activity; serine-type peptidase activity; hydrolase activity; protein binding; serine-type endopeptidase activity; signaling receptor binding;
Cellular component	extracellular matrix; plasma membrane; extracellular exosome; cytosol; extracellular region; extracellular space; azurophil granule lumen; plasma membrane raft; membrane; membrane raft; collagen-containing extracellular matrix;
Biological process	collagen catabolic process; blood coagulation; negative regulation of phagocytosis; mature conventional dendritic cell differentiation; positive regulation of cell population proliferation; antimicrobial humoral response; neutrophil degranulation; proteolysis; membrane protein ectodomain proteolysis; positive regulation of GTPase activity; cell-cell junction maintenance; neutrophil extravasation; phagocytosis; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5657
	19152
	ENSG00000277804; ENSG00000196415
	ENSMUSG00000057729
	P24158
	Q61096
	NM_002777
	NM_011178
	NP_002768
	NP_035308
	Wikidata
View/Edit Human	View/Edit Mouse

Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene.^[5]

^ ^a ^b ^c ENSG00000196415 GRCh38: Ensembl release 89: ENSG00000277804, ENSG00000196415 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057729 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". The Journal of Experimental Medicine. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764. PMID 2258701.

[refGRCh38Ensembl-1] ENSG00000196415 GRCh38: Ensembl release 89: ENSG00000277804, ENSG00000196415 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057729 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2258701-5] Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". The Journal of Experimental Medicine. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764. PMID 2258701.

[1]

[2]

[3]

[4]

[5]