Proxorphan

Proxorphan
Clinical data
ATC code
  • None
Identifiers
  • 17-(Cyclopropylmethyl)-6-oxamorphinan-3-ol
    or
    (1S,9R,10R)-17-(cyclopropylmethyl)-13-oxa-17-azatetracyclo[7.5.3.0~1,10~.0~2,7~]heptadeca-2,4,6-trien-4-ol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H25NO2
Molar mass299.414 g·mol−1
3D model (JSmol)
  • c1cc2c(cc1O)C34CCN(C(C2)C3CCOC4)CC5CC5

Proxorphan (INN), also known as proxorphan tartate (USAN) (developmental code name BL-5572M), is an opioid analgesic and antitussive drug of the morphinan family that was never marketed.[1] It acts preferentially as a κ-opioid receptor partial agonist and to a lesser extent as a μ-opioid receptor partial agonist.[2][3][4][5][6]

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1041–. ISBN 978-1-4757-2085-3.
  2. ^ Leander JD (October 1983). "Further study of kappa opioids on increased urination". The Journal of Pharmacology and Experimental Therapeutics. 227 (1): 35–41. PMID 6137557.
  3. ^ Hayes AG, Birch PJ (August 1988). "Reversal by beta-funaltrexamine and 16-methyl cyprenorphine of the antinociceptive effects of opioid agonists in the mouse and guinea-pig". Neuropharmacology. 27 (8): 813–816. doi:10.1016/0028-3908(88)90096-2. PMID 3216959. S2CID 54433737.
  4. ^ Picker MJ, Dykstra LA (May 1989). "Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists". The Journal of Pharmacology and Experimental Therapeutics. 249 (2): 557–566. PMID 2566680.
  5. ^ Picker MJ, Craft RM, Negus SS, Powell KR, Mattox SR, Jones SR, et al. (November 1992). "Intermediate efficacy mu opioids: examination of their morphine-like stimulus effects and response rate-decreasing effects in morphine-tolerant rats". The Journal of Pharmacology and Experimental Therapeutics. 263 (2): 668–681. PMID 1331411.
  6. ^ Testa B (22 October 2013). Advances in Drug Research. Elsevier. pp. 245–. ISBN 978-1-4832-8798-0.