Prp24

Prp24 (precursor RNA processing, gene 24) is a protein part of the pre-messenger RNA splicing process and aids the binding of U6 snRNA to U4 snRNA during the formation of spliceosomes. Found in eukaryotes from yeast to E. coli, fungi, and humans, Prp24 was initially discovered to be an important element of RNA splicing in 1989.[1][2] Mutations in Prp24 were later discovered in 1991 to suppress mutations in U4 that resulted in cold-sensitive strains of yeast, indicating its involvement in the reformation of the U4/U6 duplex after the catalytic steps of splicing.[3]

Prp24 RRMs 1 and 2
  1. ^ Bae, E.; et al. (2007). "Structure and interactions of the first three RNA recognition motifs of splicing factor Prp24". Journal of Molecular Biology. 367 (5): 1447–1458. doi:10.1016/j.jmb.2007.01.078. PMC 1939982. PMID 17320109.
  2. ^ Vijayraghavan, U.; Company, M.; Abelson, J. (1989). "Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae". Genes & Development. 3 (8): 1206–1216. doi:10.1101/gad.3.8.1206. PMID 2676722.
  3. ^ Shannon, K. W.; Guthrie, C. (1991). "Suppressors of U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs". Genes & Development. 5 (5): 773–785. doi:10.1101/gad.5.5.773. PMID 1827420.