Pyle is a surname. Notable people with the surname include:
- Andrew Pyle (philosopher) (born 1955), British philosopher
- Andrew Pyle (economist) (born 1963), Canadian economist
- Andy Pyle (born 1946), English bassist
- Artimus Pyle (born 1948), drummer for the rock & roll group Lynyrd Skynyrd
- Barry Pyle (born 1965), American political scientist
- Charles C. Pyle (1882–1939), American theater and sports entrepreneur
- Christopher Pyle (born 1939), American professor of politics
- David Pyle (1936–2002), English footballer
- Denver Pyle (1920–1997), American actor
- Don Pyle, Canadian record producer
- Elijah Pyle (1918–2009), English professional footballer
- Ellen Bernard Thompson Pyle (1876–1936), American illustrator
- Ernie Pyle (1900–1945), Pulitzer Prize-winning journalist
- Gladys Pyle (1890–1989), South Dakota politician
- Howard Pyle (1853–1911), American illustrator and writer
- Joey Pyle (1937–2007), British gangland boss
- John A. Pyle (born 1951), British atmospheric scientist
- John Howard Pyle (1906–1987), 12th governor of Arizona
- Katharine Pyle, (1863–1938), American author, poet, and illustrator
- Katy Pyle, American dancer and choreographer
- Kenneth B. Pyle (born 1936), Historian and professor history
- Mamie Shields Pyle, (1866–1949) American suffragist
- Mike Pyle (American football) (1939–2015), American football player with the Chicago Bears (1961–1969)
- Mike Pyle (fighter) (born 1975), American mixed martial arts fighter
- Missi Pyle (born 1972), American actress
- Nancy Pyle (1937/38–2023), American politician
- Nathan W. Pyle (born 1982), American cartoonist
- Pip Pyle (1950–2006), English drummer
- Richard Pyle (born 1967), diving marine biologist
- Richard Pyle (reporter), AP Saigon bureau chief during the Vietnam War
- Robert Michael Pyle (born 1947), American naturalist
- Steve Pyle, American cyclist
- Steve Pyle (footballer) (born 1963), English footballer