Pyrantel

Pyrantel
Clinical data
Trade namesPin-X, Combantrin, others[1]
Routes of
administration		by mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilitypoorly absorbed
Identifiers
  • 1-Methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.036.143 Edit this at Wikidata
Chemical and physical data
FormulaC11H14N2S
Molar mass206.31 g·mol−1
3D model (JSmol)
Melting point178 to 179 °C (352 to 354 °F)
  • CN1CCCN=C1/C=C/c2cccs2
  • InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+
  • Key:YSAUAVHXTIETRK-AATRIKPKSA-N

Pyrantel is a medication used to treat a number of parasitic worm infections.[2] This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis.[2] It is taken by mouth.[2]

Side effects include nausea, headache, dizziness, trouble sleeping, and rash.[2] A lower dose should be used in people with liver disease.[2] While it does not appear to be harmful during pregnancy, it has not been studied for this use.[3] It is unclear if it is safe for use during breastfeeding.[2] It is in the antihelmintic family of medications.[4] It works by paralyzing worms.[4]

Pyrantel was initially described in 1965.[5] It is on the World Health Organization's List of Essential Medicines.[6] Pyrantel is available as a generic medication.[4] It may also be used to treat worms in a number of other animals.[5]

  1. ^ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 54. ISBN 9781284057560.
  2. ^ a b c d e f World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 89, 608. hdl:10665/44053. ISBN 9789241547659.
  3. ^ "Pyrantel Use During Pregnancy". Drugs.com. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
  4. ^ a b c "Pyrantel Pamoate". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
  5. ^ a b Maddison JE, Page SW, Church DB (2008). Small Animal Clinical Pharmacology. Elsevier Health Sciences. p. 209. ISBN 978-0702028588. Archived from the original on 2016-12-20.
  6. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.