Quintus Sosius Senecio (fl. 1st century AD) was a Roman senator who was favored by the emperors Domitian and Trajan. As a result of this relationship, he was twice ordinary consul, an unusual and prestigious honor: first in 99, with Aulus Cornelius Palma Frontonianus as his colleague; and again in 107 as the colleague of Lucius Licinius Sura, who was himself consul for the third time.