| Site of Special Scientific Interest | |
 Quoisley Big Mere | |
  Location within Cheshire | |
| Location | Cheshire |
|---|---|
| Grid reference | SJ548455 |
| Coordinates | 53°00′18″N 2°40′26″W / 53.005°N 2.674°W |
| Interest | Biological |
| Area | 28.25 ha (69.8 acres) |
| Notification | 1963 |
| Natural England website | |
Quoisley Meres refers to two meres, Quoisley Big Mere and Quoisley Little Mere, near the village of Marbury, in Cheshire, England.
Glacial in origin, the meres have nutrient-rich water. The meres, fringing reed beds and surrounding damp grassland are a Site of Special Scientific Interest, and have also been designated Wetlands of International Importance, as part of the Midland Meres and Mosses Ramsar site. The meres form an important habitat for invertebrates and birds, and the site contains over a hundred plant species, including tufted-sedge, marsh fern and meadow thistle, which are all rare in Cheshire. Natural England considered the site's condition to be unfavourable in 2009.