RAD1 homolog

RAD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A1J, 3G65, 3GGR
Identifiers
Aliases	RAD1, HREC1, RAD1 homolog, RAD1 checkpoint DNA exonuclease
External IDs	OMIM: 603153; MGI: 1316678; HomoloGene: 37695; GeneCards: RAD1; OMA:RAD1 - orthologs
EC number	3.1.11.2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	34,918,989 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	10,499,149 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; nipple; ; urethra; ; visceral pleura; ; renal medulla; ; superior surface of tongue; ; ventral tegmental area; ; pylorus; ; cardia; ; Achilles tendon;
	Top expressed in
	embryo; ; epiblast; ; spermatocyte; ; ventricular zone; ; morula; ; endocardial cushion; ; ectoderm; ; otic vesicle; ; otic placode; ; medial ganglionic eminence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	damaged DNA binding; exodeoxyribonuclease III activity; protein binding; 3'-5' exonuclease activity; nuclease activity; exonuclease activity; hydrolase activity;
Cellular component	intracellular membrane-bounded organelle; chromosome; nucleoplasm; checkpoint clamp complex; nucleus;
Biological process	substantia nigra development; DNA damage checkpoint signaling; cellular response to DNA damage stimulus; DNA replication; meiotic recombination checkpoint signaling; cellular response to ionizing radiation; nucleic acid phosphodiester bond hydrolysis; regulation of signal transduction by p53 class mediator; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	5810
	19355
	ENSG00000113456
	ENSMUSG00000022248
	O60671
	Q9QWZ1
	NM_001033673; NM_002853; NM_133282; NM_133377
	NM_001289447; NM_001289448; NM_011232
	NP_002844
	NP_001276376; NP_001276377; NP_035362
	Wikidata
View/Edit Human	View/Edit Mouse

Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113456 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022248 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Freire R, Murguía JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP (September 1998). "Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis". Genes Dev. 12 (16): 2560–73. doi:10.1101/gad.12.16.2560. PMC 317084. PMID 9716408.
^ Bluyssen HA, van Os RI, Naus NC, Jaspers I, Hoeijmakers JH, de Klein A (January 1999). "A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene". Genomics. 54 (2): 331–7. doi:10.1006/geno.1998.5582. PMID 9828137.
^ "Entrez Gene: RAD1 RAD1 homolog (S. pombe)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113456 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022248 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9716408-5] Freire R, Murguía JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP (September 1998). "Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis". Genes Dev. 12 (16): 2560–73. doi:10.1101/gad.12.16.2560. PMC 317084. PMID 9716408.

[pmid9828137-6] Bluyssen HA, van Os RI, Naus NC, Jaspers I, Hoeijmakers JH, de Klein A (January 1999). "A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene". Genomics. 54 (2): 331–7. doi:10.1006/geno.1998.5582. PMID 9828137.

[entrez-7] "Entrez Gene: RAD1 RAD1 homolog (S. pombe)".

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