RAD21

RAD21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PJU, 4PJW, 4PK7
Identifiers
Aliases	RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS
External IDs	OMIM: 606462; MGI: 108016; HomoloGene: 38161; GeneCards: RAD21; OMA:RAD21 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.11 Start 116,845,934 bp[1] End 116,874,776 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 C Start 51,825,636 bp[2] End 51,855,143 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence superficial temporal artery epithelium of nasopharynx germinal epithelium cerebellar vermis pars reticulata subthalamic nucleus pars compacta trabecular bone Top expressed in Gonadal ridge human fetus left lung lobe hand tail of embryo dermis medial ganglionic eminence migratory enteric neural crest cell lobe of cerebellum genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific protein binding chromatin binding protein-containing complex binding Cellular component cytosol membrane chromosome nucleoplasm condensed nuclear chromosome nuclear chromosome chromatin chromosome, centromeric region nucleus cohesin complex nuclear matrix meiotic cohesin complex spindle pole cytoplasm cytoskeleton Biological process reciprocal meiotic recombination DNA recombination chromosome segregation regulation of transcription by RNA polymerase II transcription by RNA polymerase II cellular response to DNA damage stimulus cell division double-strand break repair cell cycle protein localization to chromatin DNA repair positive regulation of transcription by RNA polymerase II apoptotic process sister chromatid cohesion positive regulation of sister chromatid cohesion negative regulation of G2/M transition of mitotic cell cycle negative regulation of mitotic metaphase/anaphase transition meiosis multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5885 19357 Ensembl ENSG00000164754 ENSMUSG00000022314 UniProt O60216 Q61550 RefSeq (mRNA) NM_006265 NM_009009 RefSeq (protein) NP_006256 NP_033035 Location (UCSC) Chr 8: 116.85 – 116.87 Mb Chr 15: 51.83 – 51.86 Mb PubMed search [3] [4]
Wikidata
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Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene.^[5][6] RAD21 (also known as Mcd1, Scc1, KIAA0078, NXP1, HR21), an essential gene, encodes a DNA double-strand break (DSB) repair protein that is evolutionarily conserved in all eukaryotes from budding yeast to humans.  RAD21 protein is a structural component of the highly conserved cohesin complex consisting of RAD21, SMC1A, SMC3, and SCC3 [ STAG1 (SA1) and STAG2 (SA2) in multicellular organisms] proteins, involved in sister chromatid cohesion.