DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA, and yeast Rad51.[4][5] The protein is highly conserved in most eukaryotes, from yeast to humans.[6]
The name RAD51 derives from RADiation sensitive protein 51.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000051180 – Ensembl, May 2017
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- ^ Shinohara A, Ogawa H, Ogawa T (May 1992). "Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein". Cell. 69 (3): 457–70. doi:10.1016/0092-8674(92)90447-K. PMID 1581961. S2CID 35937283.
- ^ Seitz EM, Brockman JP, Sandler SJ, Clark AJ, Kowalczykowski SC (May 1998). "RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange". Genes & Development. 12 (9): 1248–53. doi:10.1101/gad.12.9.1248. PMC 316774. PMID 9573041.
- ^ Shinohara A, Ogawa H, Matsuda Y, Ushio N, Ikeo K, Ogawa T (July 1993). "Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA". Nature Genetics. 4 (3): 239–43. doi:10.1038/ng0793-239. PMID 8358431. S2CID 28220010.
- ^ Khoo, Kelvin H. P.; Jolly, Hayley R.; Able, Jason A. (2008). "The RAD51 gene family in bread wheat is highly conserved across eukaryotes, with RAD51A upregulated during early meiosis". Functional Plant Biology. 35 (12): 1267–1277. doi:10.1071/fp08203. ISSN 1445-4408. PMID 32688873.