RAMP1

RAMP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YX8, 3N7P, 3N7R, 3N7S, 4RWG
Identifiers
Aliases	RAMP1, entrez:10267, receptor activity modifying protein 1
External IDs	OMIM: 605153; MGI: 1858418; HomoloGene: 4275; GeneCards: RAMP1; OMA:RAMP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	237,912,106 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,152,918 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; ascending aorta; ; canal of the cervix; ; Descending thoracic aorta; ; right coronary artery; ; left uterine tube; ; apex of heart; ; popliteal artery; ; tibial arteries; ; gastric mucosa;
	Top expressed in
	temporal muscle; ; soleus muscle; ; sternocleidomastoid muscle; ; crypt of lieberkuhn of small intestine; ; entorhinal cortex; ; perirhinal cortex; ; olfactory tubercle; ; seminal vesicula; ; nucleus accumbens; ; masseter muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	coreceptor activity; calcitonin receptor activity; calcitonin receptor binding; protein binding; calcitonin gene-related peptide receptor activity; amylin receptor activity; calcitonin gene-related peptide binding;
Cellular component	integral component of membrane; membrane; plasma membrane; receptor complex; integral component of plasma membrane; intracellular anatomical structure; cell surface; extracellular space; amylin receptor complex 1; CGRP receptor complex;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of protein glycosylation; regulation of G protein-coupled receptor signaling pathway; receptor internalization; angiogenesis; transport; protein transport; protein localization to plasma membrane; intracellular protein transport; calcium ion transport; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to hormone stimulus; amylin receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10267
	51801
	ENSG00000132329
	ENSMUSG00000034353
	O60894
	Q9WTJ5
	NM_001308353; NM_005855
	NM_001168392; NM_016894; NM_178401
	NP_001295282; NP_005846
	NP_001161864; NP_058590; NP_848488
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.^[5]^[6]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CALCRL) to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the RAMP1 protein, CALCRL functions as the CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.^[5] The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY₁ ^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132329 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034353 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: RAMP1".
^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID 9620797. S2CID 4364526.
^ *"Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-12.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132329 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034353 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAMP1".

[pmid9620797-6] McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID 9620797. S2CID 4364526.

[IUPHAR-DB-7] *"Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-12.

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