RAMP2

RAMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RWF, 2XVT, 3AQE, 3AQF
Identifiers
Aliases	RAMP2, entrez:10266, receptor activity modifying protein 2
External IDs	OMIM: 605154; MGI: 1859650; HomoloGene: 4274; GeneCards: RAMP2; OMA:RAMP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,763,041 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,150,372 bp
RNA expression pattern
	Top expressed in
	right lung; ; gastric mucosa; ; apex of heart; ; upper lobe of left lung; ; tibial nerve; ; canal of the cervix; ; subcutaneous adipose tissue; ; right coronary artery; ; left uterine tube; ; right lobe of thyroid gland;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; left lung lobe; ; external carotid artery; ; atrium; ; internal carotid artery; ; carotid body; ; endocardial cushion; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	coreceptor activity; protein binding; adrenomedullin receptor activity; amylin receptor activity; adrenomedullin binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; receptor complex; integral component of plasma membrane; cell surface; clathrin-coated pit; lysosome; amylin receptor complex 2; adrenomedullin receptor complex;
Biological process	negative regulation of endothelial cell apoptotic process; G protein-coupled receptor signaling pathway; response to estradiol; response to hypoxia; regulation of G protein-coupled receptor signaling pathway; adherens junction assembly; response to progesterone; female pregnancy; receptor internalization; sprouting angiogenesis; basement membrane assembly; positive regulation of angiogenesis; vasculogenesis; regulation of blood pressure; heart development; cellular response to hormone stimulus; positive regulation of gene expression; positive regulation of vasculogenesis; angiogenesis; bicellular tight junction assembly; transport; protein transport; cellular response to vascular endothelial growth factor stimulus; intracellular protein transport; protein localization to plasma membrane; vascular associated smooth muscle cell development; calcium ion transport; negative regulation of vascular permeability; cAMP biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; adrenomedullin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10266
	54409
	ENSG00000131477
	ENSMUSG00000001240
	O60895
	Q9WUP0
	NM_005854
	NM_019444
	NP_005845
	NP_062317
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor activity modifying protein 2, also known as RAMP2, is a protein which in humans is encoded by the RAMP2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131477 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001240 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAMP2".
^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID 9620797. S2CID 4364526.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131477 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001240 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAMP2".

[pmid9620797-6] McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID 9620797. S2CID 4364526.

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