RAR-related orphan receptor beta

RORB
Identifiers
Aliases	RORB, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1, RAR-related orphan receptor beta, RAR related orphan receptor B, EIG15
External IDs	OMIM: 601972; MGI: 1343464; HomoloGene: 38250; GeneCards: RORB; OMA:RORB - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	74,693,177 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	19,088,560 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; parietal lobe; ; postcentral gyrus; ; retinal pigment epithelium; ; primary visual cortex; ; superior frontal gyrus; ; entorhinal cortex; ; endometrium;
	Top expressed in
	internal granular layer; ; medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; Rostral migratory stream; ; retina; ; neural layer of retina; ; retinal pigment epithelium; ; lumbar subsegment of spinal cord; ; posterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; zinc ion binding; transcription factor binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; melatonin receptor activity;
Cellular component	nucleoplasm; nucleus;
Biological process	cellular response to retinoic acid; regulation of transcription, DNA-templated; response to stimulus; rhythmic process; retinal cone cell development; negative regulation of osteoblast differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; multicellular organism development; regulation of circadian rhythm; retinal rod cell development; eye photoreceptor cell development; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; visual perception; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; amacrine cell differentiation; retina development in camera-type eye; positive regulation of transcription by RNA polymerase II; G protein-coupled receptor signaling pathway; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6096
	225998
	ENSG00000198963
	ENSMUSG00000036192
	Q92753; Q58EY0
	Q8R1B8
	NM_006914; NM_001365023
	NM_001043354; NM_001289921; NM_146095
	NP_008845; NP_001351952
	NP_001036819; NP_001276850; NP_666207
	Wikidata
View/Edit Human	View/Edit Mouse

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198963 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036192 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes & Development. 8 (5): 538–553. doi:10.1101/gad.8.5.538. PMID 7926749.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198963 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036192 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7926749-5] Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes & Development. 8 (5): 538–553. doi:10.1101/gad.8.5.538. PMID 7926749.

[1]

[2]

[3]

[4]

[5]