RELA

RELA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22
Identifiers
Aliases	RELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU
External IDs	OMIM: 164014; MGI: 103290; HomoloGene: 32064; GeneCards: RELA; OMA:RELA - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,653,599 bp[1] End 65,663,090 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 5,687,511 bp[2] End 5,698,158 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa popliteal artery tibial arteries left uterine tube cartilage tissue right lung ascending aorta Descending thoracic aorta ectocervix right coronary artery Top expressed in lactiferous gland choroid plexus of fourth ventricle granulocyte external carotid artery internal carotid artery gastrula genital tubercle mesenteric lymph nodes stroma of bone marrow right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding ankyrin repeat binding DNA-binding transcription activator activity, RNA polymerase II-specific histone deacetylase binding enzyme binding phosphate ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity chromatin binding NF-kappaB binding protein binding protein kinase binding DNA binding sequence-specific DNA binding actinin binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding chromatin DNA binding ubiquitin protein ligase binding RNA polymerase II general transcription initiation factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding protein-containing complex binding Cellular component cytoplasm cytosol I-kappaB/NF-kappaB complex transcription regulator complex NF-kappaB complex nucleoplasm nucleus nucleolus NF-kappaB p50/p65 complex protein-containing complex synapse glutamatergic synapse Biological process response to amino acid response to interleukin-1 cellular response to interleukin-6 response to progesterone response to organic substance Fc-epsilon receptor signaling pathway negative regulation of insulin receptor signaling pathway defense response to virus positive regulation of chondrocyte differentiation animal organ morphogenesis response to muscle stretch response to cytokine negative regulation of protein catabolic process cytokine-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway response to mechanical stimulus response to muramyl dipeptide stimulatory C-type lectin receptor signaling pathway transcription, DNA-templated response to insulin negative regulation of NIK/NF-kappaB signaling nucleotide-binding oligomerization domain containing 2 signaling pathway membrane protein intracellular domain proteolysis inflammatory response viral process response to cobalamin hair follicle development positive regulation of miRNA metabolic process acetaldehyde metabolic process cellular response to hepatocyte growth factor stimulus cellular response to nicotine negative regulation of apoptotic process cellular defense response response to morphine response to lipopolysaccharide cellular response to interleukin-1 response to inorganic substance regulation of inflammatory response response to cAMP negative regulation of transcription, DNA-templated response to hydrogen peroxide positive regulation of Schwann cell differentiation defense response response to bacterium response to organic cyclic compound human ageing positive regulation of cell population proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling liver development response to UV-B T cell receptor signaling pathway cellular response to lipopolysaccharide positive regulation of type I interferon production positive regulation of transcription by RNA polymerase II cellular response to hydrogen peroxide regulation of transcription, DNA-templated tumor necrosis factor-mediated signaling pathway positive regulation of transcription, DNA-templated positive regulation of T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity cellular response to peptidoglycan cellular response to tumor necrosis factor regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus positive regulation of pri-miRNA transcription by RNA polymerase II regulation of DNA-templated transcription in response to stress cellular response to lipoteichoic acid negative regulation of transcription by RNA polymerase II negative regulation of protein sumoylation pri-miRNA transcription by RNA polymerase II cellular response to angiotensin interleukin-1-mediated signaling pathway cellular response to vascular endothelial growth factor stimulus negative regulation of pri-miRNA transcription by RNA polymerase II postsynapse to nucleus signaling pathway chromatin organization I-kappaB kinase/NF-kappaB signaling NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5970 19697 Ensembl ENSG00000173039 ENSMUSG00000024927 UniProt Q04206 Q04207 RefSeq (mRNA) NM_001145138 NM_001243984 NM_001243985 NM_021975 NM_009045 NM_001365067 RefSeq (protein) NP_001138610 NP_001230913 NP_001230914 NP_068810 NP_033071 NP_001351996 Location (UCSC) Chr 11: 65.65 – 65.66 Mb Chr 19: 5.69 – 5.7 Mb PubMed search [3] [4]
Wikidata
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Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.^[5]

RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.^[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer.