RFC1

RFC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBU, 2K6G, 2K7F
Identifiers
Aliases	RFC1, RFC, replication factor C subunit 1, A1, PO-GA, RECC1, MHCBFB, RFC140, CANVAS
External IDs	OMIM: 102579; MGI: 97891; HomoloGene: 2187; GeneCards: RFC1; OMA:RFC1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	39,366,375 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	65,493,013 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ventricular zone; ; sural nerve; ; body of pancreas; ; epithelium of colon; ; testicle; ; ganglionic eminence; ; bone marrow cells; ; right adrenal cortex; ; tonsil;
	Top expressed in
	genital tubercle; ; tail of embryo; ; otic placode; ; primitive streak; ; otic vesicle; ; saccule; ; zygote; ; epiblast; ; cumulus cell; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; enzyme activator activity; ATP binding; DNA clamp loader activity; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; protein domain specific binding; DNA clamp unloader activity;
Cellular component	nucleoplasm; extracellular exosome; DNA replication factor C complex; nucleus; nucleolus; cytoplasm; Elg1 RFC-like complex; protein-containing complex;
Biological process	DNA-dependent DNA replication; nucleotide-excision repair, DNA gap filling; regulation of transcription, DNA-templated; telomere maintenance via telomerase; error-free translesion synthesis; transcription, DNA-templated; error-prone translesion synthesis; DNA replication; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; DNA repair; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of catalytic activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; telomere maintenance via semi-conservative replication; DNA clamp unloading;
	Sources:Amigo / QuickGO
Orthologs
	5981
	19687
	ENSG00000035928
	ENSMUSG00000029191
	P35251
	P35601
	NM_001204747; NM_002913; NM_001363495; NM_001363496
	NM_011258; NM_001347357; NM_001347358
	NP_001191676; NP_002904; NP_001350424; NP_001350425
	NP_001334286; NP_001334287; NP_035388
	Wikidata
View/Edit Human	View/Edit Mouse

Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000035928 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029191 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Luckow B, Bunz F, Stillman B, Lichter P, Schütz G (March 1994). "Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans". Molecular and Cellular Biology. 14 (3): 1626–34. doi:10.1128/mcb.14.3.1626. PMC 358521. PMID 8114700.
^ "Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000035928 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029191 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8114700-5] Luckow B, Bunz F, Stillman B, Lichter P, Schütz G (March 1994). "Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans". Molecular and Cellular Biology. 14 (3): 1626–34. doi:10.1128/mcb.14.3.1626. PMC 358521. PMID 8114700.

[entrez-6] "Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa".

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